Combination of inhibitors for two glycolytic enzymes portrays high synergistic efficacy against Cryptosporidium parvum

ShahbazM Khan, Muhammad Rashid Bajwa, RachaelY Lahar and WilliamH Witola

Combination of inhibitors for two glycolytic enzymes portrays high synergistic efficacy against Cryptosporidium parvum

ShahbazM Khan, Muhammad Rashid Bajwa, RachaelY Lahar and WilliamH Witola

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ShahbazM Khan (2023-09-01)

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Combination of inhibitors for two glycolytic enzymes portrays high synergistic efficacy against Cryptosporidium parvum

Combination of inhibitors for two glycolytic enzymes portrays high synergistic efficacy against Cryptosporidium parvum

Combination of inhibitors for two glycolytic enzymes portrays high synergistic efficacy against Cryptosporidium parvum

Key statements

Combination of inhibitors for two glycolytic enzymes portrays high synergistic efficacy against Cryptosporidium parvum

Abstract

T

Identification of non-toxic concentrations of compound combinations

Synergistic in vitro anti-cryptosporidial efficacy of CpPyK and CpLDH inhibitors

Anti-cryptosporidial efficacy of combinations of CpPyK and CpLDH inhibitors in infected mice

DISCUSSION

Parasites and host cells

Chemical compounds

Compound combination model

In vitro cytotoxicity assay

In vitro Cryptosporidium growth inhibition assay

Synergy analyses

Testing of the in vivo anti-Cryptosporidium efficacy of compound combina tions

References

Key statements

Abstract

T

RESULTS

Identification of non-toxic concentrations of compound combinations

Synergistic in vitro anti-cryptosporidial efficacy of CpPyK and CpLDH inhibitors

Anti-cryptosporidial efficacy of combinations of CpPyK and CpLDH inhibitors in infected mice

DISCUSSION

MATERIALS AND METHODS

Parasites and host cells

Chemical compounds

Compound combination model

In vitro cytotoxicity assay

In vitro Cryptosporidium growth inhibition assay

Synergy analyses

Testing of the in vivo anti-Cryptosporidium efficacy of compound combina tions

References

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Combination of inhibitors for two glycolytic enzymes portrays high synergistic efficacy against Cryptosporidium parvum

Combination of inhibitors for two glycolytic enzymes portrays high synergistic efficacy against Cryptosporidium parvum

Combination of inhibitors for two glycolytic enzymes portrays high synergistic efficacy against Cryptosporidium parvum

Key statements

Combination of inhibitors for two glycolytic enzymes portrays high synergistic efficacy against Cryptosporidium parvum

Abstract

T

Identification of non-toxic concentrations of compound combinations

Synergistic in vitro anti-cryptosporidial efficacy of CpPyK and CpLDH inhibitors

Anti-cryptosporidial efficacy of combinations of CpPyK and CpLDH inhibitors in infected mice

DISCUSSION

Parasites and host cells

Chemical compounds

Compound combination model

In vitro cytotoxicity assay

In vitro Cryptosporidium growth inhibition assay

Synergy analyses

Testing of the in vivo anti-Cryptosporidium efficacy of compound combina tions

References

Key statements

Abstract

T

RESULTS

Identification of non-toxic concentrations of compound combinations

Synergistic in vitro anti-cryptosporidial efficacy of CpPyK and CpLDH inhibitors

Anti-cryptosporidial efficacy of combinations of CpPyK and CpLDH inhibitors in infected mice

DISCUSSION

MATERIALS AND METHODS

Parasites and host cells

Chemical compounds

Compound combination model

In vitro cytotoxicity assay

In vitro Cryptosporidium growth inhibition assay

Synergy analyses

Testing of the in vivo anti-Cryptosporidium efficacy of compound combina tions

References